Genomic segmental polymorphisms in inbred mouse strains

被引：77

作者：

Li, JZ

Jiang, T

Mao, JH

Balmain, A

Peterson, L

Harris, C

Rao, PH

Havlak, P

Gibbs, R

Cai, WW

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA

[3] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[4] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA

来源：

NATURE GENETICS | 2004年 / 36卷 / 09期

关键词：

D O I：

10.1038/ng1417

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.

引用

页码：952 / 954

页数：3

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