Cofilin promotes actin polymerization and defines the direction of cell motility

被引：532

作者：

Ghosh, M

Song, XY

Mouneimne, G

Sidani, M

Lawrence, DS

Condeelis, JS

机构：

[1] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

来源：

SCIENCE | 2004年 / 304卷 / 5671期

关键词：

D O I：

10.1126/science.1094561

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A general caging method for proteins that are regulated by phosphorylation was used to study the in vivo biochemical action of cofilin and the subsequent cellular response. By acute and local activation of a chemically engineered, light-sensitive phosphocofilin mimic, we demonstrate that cofilin polymerizes actin, generates protrusions, and determines the direction of cell migration. We propose a role for cofilin that is distinct from its role as an actin-depolymerizing factor.

引用

页码：743 / 746

页数：4

共 27 条

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