A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of loss in breast tumors

被引：38

作者：

Kalikin, LM

Frank, TS

SvobodaNewman, SM

Wetzel, JC

Cooney, KA

Petty, EM

机构：

[1] UNIV MICHIGAN, SCH MED, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

[2] UNIV MICHIGAN, SCH MED, DEPT PATHOL, ANN ARBOR, MI 48109 USA

[3] UNIV MICHIGAN, SCH MED, DEPT SURG, ANN ARBOR, MI 48109 USA

来源：

ONCOGENE | 1997年 / 14卷 / 16期

关键词：

loss of heterozygosity; ovarian; breast; prostate; tumor suppressor; chromosome; 17q25;

D O I：

10.1038/sj.onc.1201013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromosomal regions of allelic imbalance in tumors are predicted to define the general location of tumor suppressor genes, We previously localized a putative breast tumor suppressor gene to a 3 cM region on 17q25 by deletion mapping of microsatellite markers in breast tumors, To determine if the same 17q25 region of loss is important in the genesis of other tumor types, 32 ovarian tumors and 24 prostate tumors, as well as 33 additional breast tumors, were analysed with 17q25 polymorphic microsatellite markers, While no significant loss was observed in prostate tumors, greater than half of ovarian tumors exhibited loss coincident with the candidate region previously defined in breast tumors. These results suggest that one or more novel tumor suppressor genes exist on 17q25 within a concordant region of interstitial loss defined in both breast and ovarian neoplasms.

引用

页码：1991 / 1994

页数：4

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