Comparative study of MMP-2 (matrix metalloproteinase 2) immune expression in normal uterine cervix, intraepithelial neoplasias, and squamous cells cervical carcinoma

被引：48

作者：

Gaiotto, MAM

Focchi, J

Ribalta, JLC

Stávale, JN

Baracat, EC

Lima, GR

da Silva, IDCG

机构：

[1] Univ Fed Sao Paulo, Dept Gynecol, Mol Gynecol Lab, Escola Paulista Med, BR-04039001 Sao Paulo, SP, Brazil

[2] Univ Fed Sao Paulo, Escola Paulista Med, Dept Pathol, Sao Paulo, SP, Brazil

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2004年 / 190卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

metalloproteinases; cervical intraepithelial neoplasia; cervical squamous cell carcinoma;

D O I：

10.1016/j.ajog.2003.12.017

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Objective: This study was undertaken to evaluate the levels of matrix metalloproteinase 2 (MMP2) in the precursors lesions and in the invasive cervical carcinoma and to quantify the immune reactive expression of MMP-2, using MMP-2 immunohistochemistry, in intraepithelial cervical neoplasias and in the invading cervical carcinoma. Study design: We evaluated 60 samples of cervical tissues using immunohistochemistry for MMP2 in 5 distinct groups. The groups were divided in control, cervical intraepithelial neoplasia I (CIN I), CIN II, CIN III, and cervical invading carcinoma. Results: MMP-2 expression was found gradually increased according to the degree of cervical intraepithelial neoplasia and cervical carcinoma. (Control < CIN I < CIN II < CIN III < Carcinoma) Conclusion: Our results suggest that the expression of MMP-2 can distinguish CIN I, II, and III grades and the invading carcinoma. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1278 / 1282

页数：5

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