FGF-2-mediated signal transduction during endothelial mesenchymal transformation in corneal endothelial cells

被引：86

作者：

Lee, Jeong Goo

Kay, EunDuck P.

机构：

[1] Univ So Calif, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA 90033 USA

[2] Doheny Eye Inst, Los Angeles, CA 90033 USA

来源：

EXPERIMENTAL EYE RESEARCH | 2006年 / 83卷 / 06期

关键词：

corneal endothelial cells; FGF-2; PI; 3-kinase; IL-I beta; Rho kinases; actin cytoskeleton; type I collagen; endothelial mesenchymal transformation; wound healing;

D O I：

10.1016/j.exer.2006.04.007

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

This review describes the molecular mechanism of endothelial mesenchymal transformation (EMT) mediated by fibroblast growth factor 2 (FGF-2) in corneal endothelial cells. Corneal fibrosis is rarely observed in corneal endothelium/Descemet's membrane complex; but when this pathologic tissue occurs. it causes a loss of vision. Herein, we will address the cellular activities of FGF-2 and its signaling pathways during EMT. FGF-2 has 5 isoforms: 4 nuclear high molecular weight isoforms and 1 extracellular matrix (ECM) isoform. The vast majority of studies published in the field to date have described the effect of the ECM isoform that is released into the extracellular space, from which it can access plasma membrane receptors. Our discussion will focus on the ECM isoform and its receptor-mediated signal transduction. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1309 / 1316

页数：8

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