Hydromorphone metabolites: isolation and identification from pooled urine samples of a cancer patient

被引：33

作者：

Zheng, M

McErlane, KM

Ong, MC

机构：

[1] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada

[2] St Pauls Hosp, Chron Pain Day Program, Vancouver, BC V6Z 1Y6, Canada

来源：

XENOBIOTICA | 2002年 / 32卷 / 05期

关键词：

D O I：

10.1080/00498250110119090

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Hydromorphone-3-glucuronide, dihydromorphine, dihydroisomorphine, dihydromorphine-3-glucuronide and dihydroisomorphine-3-glucuronide were isolated from a cancer patient's urine and identified as metabolites of hydromorphone by comparison with synthetic standards using LC/MS/MS with gradient elution. 2. The relative urinary recovery of dihydroisomorphine-3-glucuronide was estimated to be 17-fold higher than previously reported. 3. Three new metabolites, including hydromorphone-3-sulphate, norhydromorphone and nordihydroisomorphine, were tentatively identified.

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页码：427 / 439

页数：13

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