Lack of association of VEGF promoter polymorphisms with sporadic ALS

被引：25

作者：

Chen, W.

Saeed, M.

Mao, H.

Siddique, N.

Dellefave, L.

Hung, W. -Y.

Deng, H. -X.

Sufit, R. L.

Heller, S. L.

Haines, J. L.

Pericak-Vance, M.

Siddique, T.

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Neurol & Clin Neurosci, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA

[3] Vanderbilt Univ, Ctr Med, Ctr Human Genet Res, Nashville, TN 37232 USA

[4] Duke Univ, Ctr Med, Ctr Human Genet, Durham, NC USA

[5] NW Univ, Inst Neurosci, Dept Cell & Mol Biol, Chicago, IL USA

来源：

NEUROLOGY | 2006年 / 67卷 / 03期

关键词：

D O I：

10.1212/01.wnl.0000227926.42370.04

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

\The authors tested the association of three vascular endothelial growth factor ( VEGF) promoter polymorphisms with sporadic ALS ( SALS) to verify the results of a previous study and to investigate their modifier effects on the subphenotypes of SALS in a large family-based and case-control cohort of North American white subjects ( N = 1,603). They did not find any association of the VEGF promoter polymorphisms with SALS or its subphenotypes, suggesting that they do not have a direct causal role in ALS.

引用

页码：508 / 510

页数：3

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