SFINX-a drug-drug interaction database designed for clinical decision support systems

被引：119

作者：

Bottiger, Ylva ^{[5
]}

Laine, Kari ^{[2
,3
,4
]}

Andersson, Marine L. ^{[5
]}

Korhonen, Tuomas ^{[2
,3
,4
]}

Molin, Bjorn ^{[1
]}

Ovesjo, Marie-Louise ^{[5
]}

Tirkkonen, Tuire ^{[2
,3
,4
]}

Rane, Anders ^{[5
]}

Gustafsson, Lars L. ^{[1
,5
]}

Eiermann, Birgit ^{[1
]}

机构：

[1] Stockholm Cty Council, Dept Drug Management & Informat, SE-11891 Stockholm, Sweden

[2] Medbase Ltd, Turku, Finland

[3] Univ Turku, Dept Pharmacol Drug Dev & Therapeut, Turku, Finland

[4] TYKSLAB, Clin Pharmacol Unit, Turku, Finland

[5] Karolinska Univ Hosp, Karolinska Inst, Dept Lab Med, Div Clin Pharmacol, SE-14186 Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 2009年 / 65卷 / 06期

关键词：

Drug-drug interaction database; Clinical decision support system; Drug interactions; CARE; MANAGEMENT; KNOWLEDGE; CODEINE; ALERTS; POINT;

D O I：

10.1007/s00228-008-0612-5

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Objective The aim was to develop a drug-drug interaction database (SFINX) to be integrated into decision support systems or to be used in website solutions for clinical evaluation of interactions. Methods Key elements such as substance properties and names, drug formulations, text structures and references were defined before development of the database. Standard operating procedures for literature searches, text writing rules and a classification system for clinical relevance and documentation level were determined. ATC codes, CAS numbers and country-specific codes for substances were identified and quality assured to ensure safe integration of SFINX into other data systems. Much effort was put into giving short and practical advice regarding clinically relevant drug-drug interactions. Results SFINX includes over 8,000 interaction pairs and is integrated into Swedish and Finnish computerised decision support systems. Over 31,000 physicians and pharmacists are receiving interaction alerts through SFINX. User feedback is collected for continuous improvement of the content. Conclusion SFINX is a potentially valuable tool delivering instant information on drug interactions during prescribing and dispensing.

引用

页码：627 / 633

页数：7

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