Total synthesis of cochleamycin A

被引：48

作者：

Dineen, TA ^{[1
]}

Roush, WR ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 12期

关键词：

D O I：

10.1021/ol049331x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cochleamycin A (1) was synthesized in 2.4% overall yield via a 23-step linear sequence starting from 3-butene-1-ol. Key features of the synthesis include the synthesis of (2)-1,3-diene 21 via a Stille coupling of 4 and 5 and a transannular Diels-Alder reaction of macrocycle 26 to provide the complete carbon skeleton of 1.

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页码：2043 / 2046

页数：4

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