Function and regulation of tumor necrosis factor receptor type 2

被引：100

作者：

Carpentier, I ^{[1
]}

Coornaert, B ^{[1
]}

Beyaert, R ^{[1
]}

机构：

[1] State Univ Ghent VIB, Unit Mol Signal Transduct Inflammat, Dept Mol Biomed Res, B-9052 Ghent, Belgium

来源：

CURRENT MEDICINAL CHEMISTRY | 2004年 / 11卷 / 16期

关键词：

tumor necrosis factor Receptor (TNF-R); signal transduction; NF-kappa B; apoptosis; inflammation; CD120b; disease; polymorphisms;

D O I：

10.2174/0929867043364694

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

TNF is a major proinflammatory cytokine, which exerts its effects through two different receptors known as TNF-R1 and TNF-R2. Whereas TNF-R1 induced signaling pathways have been very well characterized during the past years, TNF-R2 has been much less well studied. Nevertheless, the function of TNF-R2 should not be underestimated, the more because this receptor shows a much more restricted but inducible expression. Several inflammatory diseases and cancers show upregulated levels of soluble TNF-R2 or are associated with TNF-R2 polymorphisms, implicating an important role for TNF-R2 as a therapeutic target. Here we will review the mechanisms that regulate TNF-R2 expression, as well as discuss TNF-R2 induced signal transduction and cross-talk with TNF-R1.

引用

页码：2205 / 2212

页数：8

共 178 条

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