Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology

被引:735
作者
Bentzen, Soren M. [1 ]
机构
[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Human Oncol, Madison, WI 53792 USA
关键词
D O I
10.1038/nrc1950
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Radiation therapy has curative or palliative potential in roughly half of all incident solid tumours, and offers organ and function preservation in most cases. Unfortunately, early and late toxicity limits the deliverable intensity of radiotherapy, and might affect the long-term health-related quality of life of the patient. Recent progress in molecular pathology and normal-tissue radiobiology has improved the mechanistic understanding of late normal-tissue effects and shifted the focus from initial-damage induction to damage recognition and tissue remodelling. This stimulates research into new pharmacological strategies for preventing or reducing the side effects of radiation therapy.
引用
收藏
页码:702 / 713
页数:12
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