Residues involved in FecR binding are localized on one side of the FecA signaling domain in Escherichia coli

被引：17

作者：

Breidenstein, Elena ^{[1
]}

Mahren, Susanne ^{[1
]}

Braun, Volkmar ^{[1
]}

机构：

[1] Univ Tubingen, D-72076 Tubingen, Germany

来源：

JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 17期

关键词：

D O I：

10.1128/JB.00741-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ferric citrate transport in Escherichia coli involves proteins encoded by the fec genes, including the transport and signaling protein FecA and the signal transducing protein FecR. Randomly isolated FecA point mutants showed a reduced interaction with FecR and a reduced transcription initiation of the ferric citrate transport genes. The mutations were localized on one side of the FecA signaling domain, which might form the interface to FecR. Some of the mutants showed strongly reduced iron transport rates, which suggests that the signaling domain affects the structure of the FecA transporter domain.

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页码：6440 / 6442

页数：3

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