Decreased expression and rare somatic mutation of the CIP1/WAF1 gene in human hepatocellular carcinoma

被引：30

作者：

Furutani, M ^{[1
]}

Arii, S ^{[1
]}

Tanaka, H ^{[1
]}

Mise, M ^{[1
]}

Niwano, M ^{[1
]}

Harada, T ^{[1
]}

Higashitsuji, H ^{[1
]}

Imamura, M ^{[1
]}

Fujita, J ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT CLIN MOL BIOL,KYOTO 60601,JAPAN

来源：

CANCER LETTERS | 1997年 / 111卷 / 1-2期

关键词：

CIP1; WAF1; p21; cyclin-dependent kinase; p53; hepatocellular carcinoma;

D O I：

10.1016/S0304-3835(96)04509-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CIP1/WAF1, a critical downstream effector of tumor suppressor p53, encodes a cyclin-dependent kinase inhibitor. By Northern blot analysis, the CIP1/WAF1 mRNA level in the tumor was significantly lower than that in the corresponding normal liver from 19 Japanese patients with hepatocellular carcinoma P <0.05). In the tumor from only one; out of 19 patients (5%), somatic mutations of the CIP1/WAF1 as well as that of p53 gene were identified by RT-PCR/SSCP analysis. These results suggest that the decreased CIP1/WAF1 expression is involved in the carcinogenesis or the progression of hepatocellular carcinoma. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：191 / 197

页数：7

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