Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana

被引：51

作者：

Chairungsrilerd, N

Furukawa, KI

Ohta, T

Nozoe, S

Ohizumi, Y

机构：

[1] TOHOKU UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT MOL BIOL,AOBA KU,SENDAI,MIYAGI 980,JAPAN

[2] TOHOKU UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOGNOSY,AOBA KU,SENDAI,MIYAGI 980,JAPAN

来源：

PLANTA MEDICA | 1996年 / 62卷 / 05期

关键词：

D O I：

10.1055/s-2006-957943

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A crude methanolic extract of the fruit hull of Mangosteen, Garcinia mongostana L. inhibited the contractions of isolated thoracic rabbit aorta induced by histamine and serotonin, The extract of the fruit hull has been fractionated by silica gel chromatography, monitoring the pharmacological activity to give alpha- and gamma-mangostin. On the basis of pharmacological data, it is suggested that alpha-mangostin and gamma-mangostin are a histaminergic and a serotonergic receptor blocking agent, respectively.

引用

页码：471 / 472

页数：2

共 6 条

[1] STUDIES IN XANTHONE SERIES .18. ISOLATION OF GAMMA-MANGOSTIN FROM GARCINIA-MANGOSTANA, AND PREPARATION OF NATURAL MANGOSTINS BY SELECTIVE DEMETHYLATION [J].