Control of absolute helicity in single-stranded abiotic metallofoldamers

被引：58

作者：

Dong, Zhenzhen ^{[1
]}

Karpowicz, Richard J., Jr. ^{[1
]}

Bai, Shi ^{[1
]}

Yap, Glenn P. A. ^{[1
]}

Fox, Joseph M. ^{[1
]}

机构：

[1] Univ Delaware, Dept Chem & Biochem, Brown Labs, Newark, DE 19716 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 44期

关键词：

D O I：

10.1021/ja065721y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Described is the design, synthesis, and characterization of abiotic, single-stranded metallofoldamers that adopt helical secondary structures upon metal complexation. The absolute helicity is determined by stereocenters at the ends of the structures and is enforced by the steric influence and hydrogen bonding ability of esters in the backbone of the foldamer. Folding of the structures is characterized in the solid state by X-ray crystallography and in solution by specific rotation, CD spectroscopy, and NMR spectroscopy. Copyright © 2006 American Chemical Society.

引用

页码：14242 / 14243

页数：2

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