NSAID-induced polyp regression in familial adenomatous polyposis patients

被引：41

作者：

Giardiello, FM

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT ONCOL,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,HEREDITARY COLORECTAL CANC CLIN & REGISTRY,BALTIMORE,MD

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 1996年 / 25卷 / 02期

关键词：

D O I：

10.1016/S0889-8553(05)70251-X

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

NSAIDs inhibit prostaglandin synthesis. In 1983, Waddell et al first reported that sulindac, a NSAID (Clinoril), caused regression of rectal adenomatous polyps in several patients with familial adenomatous polyposis, an inherited form of colorectal cancer. Subsequently, NSAIDs have been used as chemopreventive agents in animal carcinogenesis models and adenoma regression has been confirmed in human trials with sulindac. This article summarizes these developments and describes possible mechanisms of colorectal neoplasia chemoprevention.

引用

页码：349 / &

页数：14

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