Organocatalyzed asymmetric reactions via microwave activation

被引:97
作者
Mosse, Sarah [1 ]
Alexakis, Alexandre [1 ]
机构
[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva, Switzerland
关键词
D O I
10.1021/ol0614727
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Organocatalyzed asymmetric microwave-assisted reactions are described. Significant rate enhancements and a decrease of catalyst loading via microwave activation have been observed, while maintaining good to high yields and selectivities compared to literature results.
引用
收藏
页码:3577 / 3580
页数:4
相关论文
共 64 条
[1]   New strategies for organic catalysis: The first highly enantioselective organocatalytic Diels-Alder reaction [J].
Ahrendt, KA ;
Borths, CJ ;
MacMillan, DWC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (17) :4243-4244
[2]   Diamine-catalyzed asymmetric Michael additions of aldehydes and ketones to nitrostyrene [J].
Alexakis, A ;
Andrey, O .
ORGANIC LETTERS, 2002, 4 (21) :3611-3614
[3]   Theory of asymmetric organocatalysis of aldol and related reactions: Rationalizations and predictions [J].
Allemann, C ;
Gordillo, R ;
Clemente, FR ;
Cheong, PHY ;
Houk, KN .
ACCOUNTS OF CHEMICAL RESEARCH, 2004, 37 (08) :558-569
[4]   The use of N-alkyl-2,2′-bipyrrolidine derivatives as organocatalysts for the asymmetric Michael addition of ketones and aldehydes to nitroolefins [J].
Andrey, O ;
Alexakis, A ;
Tomassini, A ;
Bernardinelli, G .
ADVANCED SYNTHESIS & CATALYSIS, 2004, 346 (9-10) :1147-1168
[5]   Organocatalytic Michael addition, a convenient tool in total synthesis. First asymmetric synthesis of (-)-botryodiplodin [J].
Andrey, O ;
Vidonne, A ;
Alexakis, A .
TETRAHEDRON LETTERS, 2003, 44 (43) :7901-7904
[6]   Asymmetric Michael addition of α-hydroxyketones to nitroolefins catalyzed by chiral diamine [J].
Andrey, O ;
Alexakis, A ;
Bernardinelli, G .
ORGANIC LETTERS, 2003, 5 (14) :2559-2561
[7]  
[Anonymous], EUR J ORG CHEM
[8]  
Berkessel A, 2005, ASYMMETRIC ORGANOCATALYSIS: FROM BIOMIMETIC CONCEPTS TO APPLICATIONS IN ASYMMETRIC SYNTHESIS, P1, DOI 10.1002/3527604677
[9]   Direct catalytic asymmetric aldol reactions of aldehydes [J].
Bogevig, A ;
Kumaragurubaran, N ;
Jorgensen, KA .
CHEMICAL COMMUNICATIONS, 2002, (06) :620-621
[10]   A proline-catalyzed asymmetric Robinson annulation reaction [J].
Bui, T ;
Barbas, CF .
TETRAHEDRON LETTERS, 2000, 41 (36) :6951-6954