New flavin and deazaflavin oligonucleotide conjugates for the amperometric detection of DNA hybridization

被引：7

作者：

Cosnier, S

Gondran, C

Dueymes, C

Simon, P

Fontecave, M

Décout, JL

机构：

[1] Univ Grenoble 1, CNRS, Inst Chim Mol Grenoble, Lab Electrochim Organ & Photochim Redox,UMR 5630, F-38041 Grenoble 9, France

[2] UJF, CEA Grenoble, CNRS,UMR 5047,DRDC CB, Lab Chim & Biochim, F-38054 Grenoble, France

[3] UJF, CEA Grenoble, CNRS,UMR 5047,DRDC CB, Ctr Redox Biol, F-38054 Grenoble 09, France

[4] Univ Grenoble 1, CNRS, Dept Pharmacochim Mol, UMR 5063,Lab Chim Bioorgan, F-38243 Meylan, France

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 14期

关键词：

D O I：

10.1039/b402760d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The functionalization of an oligonucleotide by flavin and deazaflavin derivatives allowed an amperometric determination of the hybridization process through the disappearance of the electroactivity of the free oligonucleotide and the appearance of a new electrochemical signal characteristic of the resulting duplex.

引用

页码：1624 / 1625

页数：2

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