Mycobacterium leprae is naturally resistant to PA-824

被引：33

作者：

Manjunatha, Ujjini H.

Lahiri, Ramanuj

Randhawa, Baljit

Dowd, Cynthia S.

Krahenbuhl, James L.

Barry, Clifton E., III

机构：

[1] NIAID, Tuberculosis Res Sect, Rockville, MD 20852 USA

[2] Louisiana State Univ, Lab Res Branch, Natl Hansens Dis Program, Baton Rouge, LA 70803 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 10期

关键词：

D O I：

10.1128/AAC.00488-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Leprosy responds very slowly to the current multidrug therapy, and hence there is a need for novel drugs with potent bactericidal activity. PA-824 is a 4-nitroimidazo-oxazine that is currently undergoing phase I clinical trials for the treatment of tuberculosis. The activity of PA-824 against Mycobacterium leprae was tested and compared with that of rifampin in axenic cultures, macrophages, and two different animal models. Our results conclusively demonstrate that PA-824 has no effect on the viability of M. leprae in all three models, consistent with the lack of the nitroimidazo-oxazine-specific nitroreductase, encoded by Rv3547 in the M. leprae genome, which is essential for activation of this molecule.

引用

页码：3350 / 3354

页数：5

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