Increasing CNS norepinephrine levels by the precursor L-DOPS facilitate beam-walking recovery after sensorimotor cortex ablation in rats

被引:30
作者
Kikuchi, K [1 ]
Nishino, K [1 ]
Ohyu, H [1 ]
机构
[1] Akita Univ, Sch Med, Dept Neurosurg, Akita 0108543, Japan
关键词
functional recovery; norepinephrine; sensorimotor cortex; hemiplegia; L-DOPS; beam-walking performance; cortex ablation;
D O I
10.1016/S0006-8993(00)02034-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The present investigation was conducted to document a role of L-threo-3,4-dihydroxyphenylserine (L-DOPS), precursor of L-norepinephrine (NE), in the functional recovery from beam-walking performance deficits in rats after unilateral sensorimotor cortex ablation. L-DOPS was administered simultaneously with benserazide (BSZ; a peripheral aromatic amino acid decarboxylase inhibitor), and the regional contents of NE in the cerebral cortex, hippocampus, and cerebellum were assayed. Behavioral recovery was demonstrated by the rats treated with L-DOPS and BSZ, and the rare of recovery was significantly different from chat of richer BSZ-troated or vehicle-treated control rats. The NE tissue levels in the three discrete regions of the rat brain were significantly elevated in the experimental rats receiving both L-DOPS and BSZ. The present studies indicate that increasing NE levels by the precursor L-DOPS may be responsible for facilitating behavioral recovery from beam-walking performance deficits in rats, and further suggest that L-DOPS may become one of the candidate compounds for further clinical human trials promoting functional recovery after injuries to the cerebral cortex. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:130 / 135
页数:6
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