PATERNAL DEPRIVATION DURING INFANCY RESULTS IN DENDRITE- AND TIME-SPECIFIC CHANGES OF DENDRITIC DEVELOPMENT AND SPINE FORMATION IN THE ORBITOFRONTAL CORTEX OF THE BIPARENTAL RODENT OCTODON DEGUS

被引:76
作者
Helmeke, C. [1 ]
Seidel, K. [1 ]
Poeggel, G. [3 ]
Bredy, T. W. [2 ]
Abraham, A. [1 ]
Braun, K. [1 ]
机构
[1] Otto von Guericke Univ, Dept Zool Dev Neurobiol, D-39120 Magdeburg, Germany
[2] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
[3] Univ Leipzig, Dept Human Biol, D-04103 Leipzig, Germany
关键词
paternal care; social deprivation; prefrontal cortex; limbic system; rats; ANTERIOR CINGULATE CORTEX; PEROMYSCUS-CALIFORNICUS; PYRAMIDAL NEURONS; MATERNAL-CARE; INTERGENICULATE LEAFLET; COGNITIVE-DEVELOPMENT; REPRODUCTIVE SUCCESS; AUDITORY-CORTEX; PUP DEVELOPMENT; FEMALE RATS;
D O I
10.1016/j.neuroscience.2009.07.008
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
The aim of this study in the biparental rodent Octodon degus was to assess the impact of paternal deprivation on neuronal and synaptic development in the orbitofrontal cortex, a prefrontal region which is essential for emotional and cognitive function. On the behavioral level the quantitative comparison of parental behaviors in biparental and single-mother families revealed that (i) degu fathers significantly participate in parental care and (ii) single-mothers do not increase their maternal care to compensate the lack of paternal care. On the brain structural level we show in three-week-old father-deprived animals that layer II/III pyramidal neurons in the orbitofrontal cortex displayed significantly lower spine densities on apical and basal dendrites. Whereas biparentally raised animals have reached adult spine density values at postnatal day 21, fatherless animals seem "to catch up" by a delayed increase of spine density until reaching similar values as biparentally raised animals in adulthood. However, in adulthood reduced apical spine numbers together with shorter apical dendrites were observed in father-deprived animals, which indicates that dendritic growth and synapse formation (seen in biparental animals between postnatal day 21 and adulthood) were significantly suppressed. These results demonstrate that paternal deprivation delays and partly suppresses the development of orbitofrontal circuits. The retarded dendritic and synaptic development of the apical dendrites of layer II/III pyramidal neurons in the orbitofrontal cortex of adult fatherless animals may reflect a reduced excitatory connectivity of this cortical subregion. (c) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:790 / 798
页数:9
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