Warning! Nearby construction can profoundly affect your experiments

被引:31
作者
Dallman, MF [1 ]
Akana, SF [1 ]
Bell, ME [1 ]
Bhatnagar, S [1 ]
Choi, S [1 ]
Chu, A [1 ]
Gomez, F [1 ]
Laugero, K [1 ]
Soriano, L [1 ]
Viau, V [1 ]
机构
[1] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
关键词
food intake; body weight; phenotypic expression; rhythms;
D O I
10.1385/ENDO:11:2:111
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This is meant to alert people to potentially major effects of construction projects on research results, Because we study the effects of stress on regulation of ACTH and corticosterone secretion and of serotonin receptors and stress on energy balance, we serve as an early warning system when things go awry, Most of our experiments include taking daily, or twice daily, measurements of rat or mouse weights and food intake as well as stress hormone levels. We are highly sensitized to environmental disruption and we've shown previously the effects of construction on stress hormones (1). However, we did not anticipate the change and disruption in energy balance that may occur in response to environmental perturbation. We provide two examples of these, below.
引用
收藏
页码:111 / 113
页数:3
相关论文
共 5 条
[1]  
Akana, 1996, Stress, V1, P33, DOI 10.3109/10253899609001094
[2]  
DALLMAN MF, 1999, HDB PHYSL, V8
[3]  
DALLMAN MF, 1994, SEMIN NEUROSCI, V6, P205
[4]  
Felig P., 1995, ENDOCRINOLOGY METABO
[5]   Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene [J].
Nonogaki, K ;
Strack, AM ;
Dallman, MF ;
Tecott, LH .
NATURE MEDICINE, 1998, 4 (10) :1152-1156