8-methoxyquinoline-5-carboxamides as PDE4 inhibitors: A potential treatment for asthma

被引：15

作者：

Buckley, GM

Cooper, N

Dyke, HJ

Galleway, FP

Gowers, L

Haughan, AF

Kendall, HJ

Lowe, C

Maxey, R

Montana, JG

Naylor, R

Oxford, J

Peake, JC

Picken, CL

Runcie, KA

Sabin, V

Sharpe, A

Warneck, JBH

机构：

[1] Celltech R&D, Cambridge CB1 6GS, England

[2] Univ Bradford, Dept Pharmacol, Bradford BD7 1DP, W Yorkshire, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(02)00223-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of bicyclic heteroaryl ring systems was considered as a replacement for the 3 -cyclopentyloxy-4-methoxyphenyl moiety in rolipram resulting in the discovery of 8-methoxyquinoline-5-carboxamides as potent inhibitors of phosphodiesterase type 4 (PDE4). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1613 / 1615

页数：3

共 23 条

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