Synthesis of (2R,5S)- and (2S,5S)-2-carboxy-1,4-diaza-[4.3.0]bicyclononane as building blocks for the synthesis of new potential HIV protease inhibitors.

被引：12

作者：

Falorni, M

Porcheddu, A

Giacomelli, G

机构：

[1] Dipartimento di Chimica, Università di Sassari, I-07100 Sassari

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 07期

关键词：

D O I：

10.1016/0957-4166(96)00241-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A procedure for the preparation of optically active (2R,5S)- and (2S,5S)-2-Carboxy-1,4-diaza-[4.3.0]bicyclononane is described. The method is based on the reduction of diketopiperazines obtained from cyclization of Pro-L-Ser or Pro-D-Ser and occurs without loss of enantiomeric purity. The synthesis is based on readily available starting materials and can be easily arranged for multigram scale preparations. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1999 / 2005

页数：7

共 11 条

[1] ASYMMETRIC REDUCTION OF PROCHIRAL KETONES WITH CHIRAL HYDRIDE REAGENTS PREPARED FROM LITHIUM ALUMINUM-HYDRIDE AND (S)-2-(N-SUBSTITUTED AMINOMETHYL)PYRROLIDINES [J].