Antibiofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation

被引：29

作者：

Ballard, T. Eric ^{[1
]}

Richards, Justin J. ^{[1
]}

Aquino, Arianexys ^{[1
]}

Reed, Catherine S. ^{[1
]}

Melander, Christian ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 04期

关键词：

PSEUDOMONAS-AERUGINOSA BIOFILMS; BACTERIAL BIOFILMS; ACINETOBACTER-BAUMANNII; BIOMIMETIC SYNTHESIS; CYSTIC-FIBROSIS; INFECTIONS; INHIBITION; ANALOGS; 2-AMINOIMIDAZOLES; DERIVATIVES;

D O I：

10.1021/jo802260t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diverse 20-compound library of analogues based on the marine alkaloid oroidin were synthesized via a reductive acylation strategy. The final target was then assayed for inhibition and dispersion activity against common proteo-bacteria known to form biofilms. This methodology represents a significant improvement over the generality of known methods to acylate substrates containing 2-aminoimidazoles and has the potential to have broad application to the synthesis of more advanced oroidin family members and their corresponding analogues.

引用

页码：1755 / 1758

页数：4

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