Association study of angiotensin I-converting enzyme polymorphism and symptomatology and antidepressant response in major depressive disorders

被引:40
作者
Hong, CJ
Wang, YC
Tsai, SJ
机构
[1] Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei 112, Taiwan
[3] Yu Li Vet Hosp, Sect Psychiat, Hualien, Taiwan
关键词
association; major depressive disorders; polymorphism; angiotensin-converting enzyme; treatment response;
D O I
10.1007/s00702-001-0686-z
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Angiotensin-converting enzyme (ACE) inhibitor has mood-elevating effects, and central ACE activity is increased for suicidal patients. In addition, substance P (SP), which is degraded by ACE, has been implicated in the pathogenesis of, and evaluated in the treatment for, major depressive disorder (MDD). The present study has tested the hypothesis that an ACE-gene insertion/deletion (I/D) polymorphism is associated with onset age, clinical manifestations, suicide history, and/or antidepressant response for two groups of MDD patients. No significant differences were demonstrated for onset age (p = 0.520), suicide history (p = 0.823), or baseline, total and cluster scores for Hamilton Depression Rating Scale comparing the three ACE genotypes. Further, previous findings that this ACE polymorphism is associated with therapeutic antidepressant effects were not replicated. The results demonstrate that these ACE variants did not play, a major role in the clinical manifestations or antidepressant response for our MDD patients.
引用
收藏
页码:1209 / 1214
页数:6
相关论文
共 24 条
[1]   An insertion/deletion polymorphism in the angiotensin converting enzyme gene is associated with both brain substance P contents and affective disorders [J].
Arinami, T ;
Li, LM ;
Mitsushio, H ;
Itokawa, M ;
Hamaguchi, H ;
Toru, M .
BIOLOGICAL PSYCHIATRY, 1996, 40 (11) :1122-1127
[2]   REDUCED ACTIVITY OF ANGIOTENSIN-CONVERTING ENZYME IN BASAL GANGLIA IN EARLY ONSET SCHIZOPHRENIA [J].
ARREGUI, A ;
MACKAY, AVP ;
SPOKES, EG ;
IVERSEN, LL .
PSYCHOLOGICAL MEDICINE, 1980, 10 (02) :307-313
[3]   Possible influence of the insertion/deletion polymorphism in the angiotensin I-converting enzyme gene on therapeutic outcome in affective disorders [J].
Baghai, TC ;
Schüle, C ;
Zwanzger, P ;
Minov, C ;
Schwarz, MJ ;
de Jonge, S ;
Rupprecht, R ;
Bondy, B .
MOLECULAR PSYCHIATRY, 2001, 6 (03) :258-259
[4]  
DUX S, 1984, ISRAEL J MED SCI, V20, P1138
[5]  
Furlong RA, 2000, AM J MED GENET, V96, P733, DOI 10.1002/1096-8628(20001204)96:6<733::AID-AJMG7>3.0.CO
[6]  
2-8
[7]   Evidence of a possible role of altered angiotensin function in the treatment, but not etiology, of depression [J].
Gard, PR ;
Mandy, A ;
Sutcliffe, MA .
BIOLOGICAL PSYCHIATRY, 1999, 45 (08) :1030-1034
[8]  
Guy W., 1976, ECDEU ASSESSMENT MAN, P217, DOI DOI 10.1016/J.BIOPHA.2016.11.034
[9]  
Hamilton M., 1967, British Journal of Social and Clinical Psychology, V6, P278
[10]   BIOCHEMISTRY AND PHARMACOLOGY OF THE RENIN-ANGIOTENSIN SYSTEM [J].
JOHNSTON, CI .
DRUGS, 1990, 39 :21-31