A convenient and genuine equivalent to HZrCp2Cl generated in situ from ZrCp2Cl2-DIBAL-H

被引：149

作者：

Huang, Zhihong ^{[1
]}

Negishi, Ei-ichi ^{[1
]}

机构：

[1] Purdue Univ, Herbert C Brown Labs Chem, W Lafayette, IN 47907 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 17期

关键词：

D O I：

10.1021/ol061202o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Slow addition of 1 equiv of (Bu2AlH)-Bu-i to ZrCp2Cl2 in THF provides a convenient route to either HZrCp2Cl-(Bu2AlCl)-Bu-i (Reagent I) or HZrCp2Cl (Reagents II and III). The latter represents a highly convenient route to genuine HZrCp2Cl, while Reagent I is useful for regio- and stereoselective conversion of 1- and 2-alkynes into (E)-1-iodo-1-alkenes and (E)-2-iodo-2-alkenes, respectively.

引用

页码：3675 / 3678

页数：4

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