Calystegine alkaloids from Duboisia leichhardtii

被引：23

作者：

Kato, A

Asano, N

Kizu, H

Matsui, K

Suzuki, S

Arisawa, M

机构：

[1] HOKURIKU UNIV,FAC PHARMACEUT SCI,KANAZAWA,ISHIKAWA 92011,JAPAN

[2] TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,TOYAMA 93001,JAPAN

来源：

PHYTOCHEMISTRY | 1997年 / 45卷 / 02期

关键词：

Duboisia leichhardtii; Solanaceae; calystegine C-1; calystegine C-2; pentahydroxy-nor-tropane; alpha-mannosidase inhibitor;

D O I：

10.1016/S0031-9422(96)00865-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pentahydroxy-nor-tropane alkaloids, calystegines C-1 and C-2, were isolated from the leaves of greenhouse-cultivated Duboisia leichhardtii, together with calystegines B-1, B-2 and B-4. Calystegine C-1 is a potent inhibitor of beta-glucosidase and beta-galactosidase, whereas calystegine C-2 exhibited no significant inhibitory activity against these enzymes. Only calystegine C-2, the 2-epimer of calystegine C-1, among calystegines isolated to date exhibited an inhibitory activity against all alpha-mannosidases tested. (C) 1997 Elsevier Science Ltd.

引用

页码：425 / 429

页数：5

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