Selection of multiple-antibiotic-resistant (Mar) mutants of Escherichia coli by using the disinfectant pine oil: Roles of the mar and acrAB loci

被引：143

作者：

Moken, MC

McMurry, LM

Levy, SB

机构：

[1] TUFTS UNIV,SCH MED,DEPT MOL BIOL & MICROBIOL,BOSTON,MA 02111

[2] TUFTS UNIV,SCH MED,DEPT MED,BOSTON,MA 02111

[3] TUFTS UNIV,SCH MED,CTR ADAPTAT GENET & DRUG RESISTANCE,BOSTON,MA 02111

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 12期

关键词：

D O I：

10.1128/AAC.41.12.2770

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mutants of Escherichia coli selected for resistance to the disinfectant pine oil or to a household product containing pine oil also showed resistance to multiple antibiotics (tetracycline, ampicillin, chloramphenicol, and nalidixic acid) and overexpressed the marA gene. Likewise, antibiotic-selected Mar mutants, which also overexpress marA, were resistant to pine oil. Deletion of the mar or acrAB locus, the latter encoding a multidrug efflux pump positively regulated in part by MarA, increased the susceptibility of wild-type and mutant strains to pine oil.

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页码：2770 / 2772

页数：3

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