Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE

被引：55

作者：

Frazer, DM

Wilkins, SJ

Millard, KN

McKie, AT

Vulpe, CD

Anderson, GJ

机构：

[1] Queensland Inst Med Res, Iron Metab Lab, Brisbane, Qld 4006, Australia

[2] Univ Queensland, PO Royal Brisbane Hosp, Brisbane, Qld, Australia

[3] Univ London Kings Coll, Div Life Sci, London W8 7AH, England

[4] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2004年 / 126卷 / 03期

关键词：

hepcidin; HFE; iron metabolism; acute phase response; transferrin saturation;

D O I：

10.1111/j.1365-2141.2004.05044.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of HFE inactivation on iron homeostasis during an acute phase response was investigated in mice. HFE knockout, beta(2)-microglobulin knockout and C57BL/6J mice were injected with Freund's Complete Adjuvant to induce an acute phase response and hepatic hepcidin expression and serum transferrin saturation was determined 16 h later. Hepcidin mRNA increased in all strains in response to an acute phase stimulus when compared with untreated control animals. Hypoferraemia also occurred in all strains, indicating that both the upregulation of hepcidin and the decrease in transferrin saturation associated with an acute phase response is not dependent on HFE function.

引用

页码：434 / 436

页数：3

共 12 条

[1] Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption
Anderson, GJ
Frazer, DM
Wilkins, SJ
Becker, EM
Millard, KN
Murphy, TL
McKie, AT
Vulpe, CD
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2002, 30 : 724 - 726
[2] Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
Bridle, KR
Frazer, DM
Wilkins, SJ
Dixon, JL
Purdie, DM
Crawford, DHG
Subramaniam, VN
Powell, LW
Anderson, GJ
Ramm, GA
[J]. LANCET, 2003, 361 (9358) : 669 - 673
[3] Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1
Fleming, RE
Migas, MC
Zhou, XY
Jiang, JX
Britton, RS
Brunt, EM
Tomatsu, S
Waheed, A
Bacon, BR
Sly, WS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) : 3143 - 3148
[4] Mechanisms of iron accumulation in hereditary hemochromatosis
Fleming, RE
Sly, WS
[J]. ANNUAL REVIEW OF PHYSIOLOGY, 2002, 64 : 663 - 680
[5] The orchestration of body iron intake: how and where do enterocytes receive their cues?
Frazer, DM
Anderson, GJ
[J]. BLOOD CELLS MOLECULES AND DISEASES, 2003, 30 (03) : 288 - 297
[6] Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins
Frazer, DM
Vulpe, CD
McKie, AT
Wilkins, SJ
Trinder, D
Cleghorn, GJ
Anderson, GJ
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2001, 281 (04): : G931 - G939
[7] Iron, infections, and anemia of inflammation
Jurado, RL
[J]. CLINICAL INFECTIOUS DISEASES, 1997, 25 (04) : 888 - 895
[8] The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
Nicolas, G
Chauvet, C
Viatte, L
Danan, JL
Bigard, X
Devaux, I
Beaumont, C
Kahn, A
Vaulont, S
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (07) : 1037 - 1044
[9] Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
Nicolas, G
Bennoun, M
Devaux, I
Beaumont, C
Grandchamp, B
Kahn, A
Vaulont, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) : 8780 - 8785
[10] Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man
Santos, M
Schilham, MW
Rademakers, LHPM
Marx, JJM
deSousa, M
Clevers, H
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (05) : 1975 - 1985

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