Outbreak of infection by carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-58 in Belgium

被引:55
作者
Bogaerts, Pierre
Naas, Thierry
Wybo, Ingrid
Bauraing, Caroline
Soetens, Oriane
Pierard, Denis
Nordmann, Patrice
Glupczynski, Youri
机构
[1] Clin Univ UCL Mt Godinne, Bacteriol Lab, B-5530 Yvoir, Belgium
[2] Univ Paris 11, Fac Med Paris Sud, Assistance Publ Hop Paris, Hop Bicetre,Serv Bacteriol Virol, Le Kremlin Bicetre, France
[3] Free Univ Brussels, Akad Ziekenhuis, Dienst Microbiol & Ziekenhuishyg, B-1090 Brussels, Belgium
关键词
D O I
10.1128/JCM.00796-06
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Carbapenem-resistant Acinetobacter baumannii isolates were obtained from 17 patients between September 2004 and August 2005 at the Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium. These multidrug-resistant isolates, which belonged to a single clone, remained susceptible to colistin and tigecycline only and produced the carbapenem-hydrolyzing oxacillinase OXA-58. This study highlights the importance of the intercountry spread of this P-lactamase-mediated resistance mechanism and its epidemic evolution.
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收藏
页码:4189 / 4192
页数:4
相关论文
共 24 条
[1]   Characterization of OXA-25, OXA-26, and OXA-27, molecular class D β-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii [J].
Afzal-Shah, M ;
Woodford, N ;
Livermore, DM .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (02) :583-588
[2]   Acinetobacter spp, as nosocomial pathogens: Microbiological, clinical, and epidemiological features [J].
BergogneBerezin, E ;
Towner, KJ .
CLINICAL MICROBIOLOGY REVIEWS, 1996, 9 (02) :148-+
[3]   Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina [J].
Brown, S ;
Young, HK ;
Amyes, SGB .
CLINICAL MICROBIOLOGY AND INFECTION, 2005, 11 (01) :15-23
[4]   OXA β-lactamases in Acinetobacter:: the story so far [J].
Brown, S ;
Amyes, S .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 57 (01) :1-3
[5]   Imipenem resistance among Acinetobacter baumannii: Association with reduced expression of a 33-36 kDa outer membrane protein [J].
Clark, RB .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 38 (02) :245-251
[6]  
Clinical and Laboratory Standards, 2005, PERF STAND ANT SUSC
[7]   Occurrence of OXA-58-like carbapenemases in Acinetobacter spp. collected over 10 years in three continents [J].
Coelho, J ;
Woodford, N ;
Afzal-Shah, M ;
Livermore, D .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (02) :756-758
[8]   IMIPENEM RESISTANCE IN ACINETOBACTER-BAUMANNII IS DUE TO ALTERED PENICILLIN-BINDING PROTEINS [J].
GEHRLEIN, M ;
LEYING, H ;
CULLMANN, W ;
WENDT, S ;
OPFERKUCH, W .
CHEMOTHERAPY, 1991, 37 (06) :405-412
[9]   Contribution of acquired carbapenem-hydrolyzing oxacillinases to carbapenem resistance in Acinetobacter baumannii [J].
Héritier, C ;
Poirel, L ;
Lambert, T ;
Nordmann, P .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (08) :3198-3202
[10]   A nosocomial outbreak of Acinetobacter baumannii isolates expressing the carbapenem-hydrolysing oxacillinase OXA-58 [J].
Héritier, C ;
Dubouix, A ;
Poirel, L ;
Marty, N ;
Nordmann, P .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 55 (01) :115-118