Dynamic expression of R-spondin family genes in mouse development

被引：104

作者：

Nam, Ju-Suk ^{[1
]}

Turcotte, Taryn J. ^{[1
]}

Yoon, Jeong Kyo ^{[1
]}

机构：

[1] Maine Med Ctr, Res Inst, Ctr Mol Med, Scarborough, ME 04074 USA

来源：

GENE EXPRESSION PATTERNS | 2007年 / 7卷 / 03期

关键词：

R-spondin; Wnt; frizzled; LRP5/6; beta-catenin; mouse embryogenesis; gene expression;

D O I：

10.1016/j.modgep.2006.08.006

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

R-spondins (Rspo) are a recently discovered secretory protein family with four members in human and mouse. We and others demonstrated that R-spondins can activate canonical Writ signaling and beta-catenin-dependent gene expression. Our study further demonstrated that R-spondins are novel ligands for the Frizzled8 and LRP6 (LDL-receptor-related protein 6) receptors. To gain insight into their biological functions, the RNA expression pattern of the mouse R-spondin family genes was analyzed during mouse development. Our study shows that R-spondin gene transcripts are widely expressed with distinct patterns in mouse at different developmental stages. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：306 / 312

页数：7

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