Comparative in vitro activity of S-4661, a new parenteral carbapenem, and other antimicrobial agents against respiratory pathogens

被引：25

作者：

Watanabe, A ^{[1
]}

Takahashi, H ^{[1
]}

Kikuchi, T ^{[1
]}

Kobayashi, T ^{[1
]}

Gomi, K ^{[1
]}

Fujimura, S ^{[1
]}

Tokue, Y ^{[1
]}

Nukiwa, T ^{[1
]}

机构：

[1] Tohoku Univ, Inst Dev Aging & Canc, Dept Resp Oncol & Mol Med, Sendai, Miyagi 9808575, Japan

来源：

CHEMOTHERAPY | 2000年 / 46卷 / 03期

关键词：

S-4661; carbapenem; antimicrobial activity; respiratory pathogens; Pseudomonas aeruginosa;

D O I：

10.1159/000007276

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The activity of S-4661, a new parenteral carbapenem antibiotic, was evaluated against 202 recent clinical isolates of respiratory pathogens. S-4661 was similar to or 2 times more active than imipenem, meropenem, and biapenem, and 8-128 times more active than ceftazidime against gram-positive bacteria. Against gram-negative bacteria, S-4661 was slightly less active than meropenem, but 2-8 times more active than the other agents. In particular, against Pseudomonas aeruginosa S-4661 showed the most potent activity. Thus it was found that S-4661 possesses a potent and well-balanced activity against respiratory pathogens. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：184 / 187

页数：4

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