Ethical and Scientific Implications of the Globalization of Clinical Research

被引：460

作者：

Glickman, Seth W. ^{[1
,3
]}

McHutchison, John G. ^{[1
,2
]}

Peterson, Eric D. ^{[1
,2
]}

Cairns, Charles B. ^{[1
,3
]}

Harrington, Robert A. ^{[1
,2
]}

Califf, Robert M. ^{[1
,2
]}

Schulman, Kevin A. ^{[1
,2
]}

机构：

[1] Duke Univ, Sch Med, Duke Clin Res Inst, Duke Translat Med Inst,Ctr Clin & Genet Econ, Durham, NC 27715 USA

[2] Duke Univ, Sch Med, Dept Med, Durham, NC 27715 USA

[3] Univ N Carolina, Sch Med, Dept Emergency Med, Chapel Hill, NC USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 360卷 / 08期

关键词：

MEDICAL-RESEARCH; HEALTH RESEARCH; TRIALS; CONDUCT; BARRIERS; DESIGN; FUTURE;

D O I：

10.1056/NEJMsb0803929

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 61-year-old man presents to the emergency room with left-sided epistaxis that has continued for 1 hour. He estimates having lost approximately 1/2 cup of blood and reports no history of nasal obstruction, epistaxis, trauma, bleeding diathesis, or easy bruising. He has a history of hypertension. Medications include atenolol and baby aspirin. How should this patient be evaluated and treated? Copyright © 2009 Massachusetts Medical Society.All rights reserved.

引用

页码：816 / 823

页数：8

共 58 条

[1] Industry-sponsored research in developing countries [J].

Abbas, E. E. .

CONTEMPORARY CLINICAL TRIALS, 2007, 28 (06) :677-683

[2] The ethics of clinical research in the Third World [J].

Angell, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (12) :847-849

[3] Human rights and maternal-fetal HIV transmission prevention trials in Africa [J].

Annas, GJ ;

Grodin, MA .

AMERICAN JOURNAL OF PUBLIC HEALTH, 1998, 88 (04) :560-563

[4]

[Anonymous], ETH CLIN RES DEV COU

[5]

[Anonymous], 2018, Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects

[6]

[Anonymous], 2002, International ethical guidelines for biomedical research involving human subjects

[7]

Bailey WCC., MAKE YOUR MOVE TAKIN

[8] International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis [J].

Bhatt, DL ;

Steg, PG ;

Ohman, EM ;

Hirsch, AT ;

Ikeda, Y ;

Mas, JL ;

Goto, S ;

Liau, CS ;

Richard, AJ ;

Röther, J ;

Wilson, PWF ;

Andersen-Dalheim, H ;

Anderson, P ;

Anell, B ;

Arber, S ;

Armstrong, K ;

Arnot, D ;

Baldam, A ;

Barratt, I ;

Barresi, S ;

Beder, J ;

Benson, M ;

Bergman, F ;

Best, J ;

Bhasim, R ;

Bovell, G ;

Bowman, N ;

Brkic, M ;

Bromberger, D ;

Brown, D ;

Brown, J ;

Brownstein, M ;

Bruce, A ;

Buonopane, J ;

Burns, S ;

Butler, A ;

Byrne, D ;

Carson, J ;

Cassimatis, P ;

Chaffey, G ;

Chambers, D ;

Chan, WJ ;

Chan, B ;

Cheatham, J ;

Chen, R ;

Cheong, B ;

Cheung, C ;

Chin, J ;

Chiu, A ;

Choo, E .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (02) :180-189

[9] The global burden of asthma [J].

Braman, Sidney S. .

CHEST, 2006, 130 (01) :4S-12S

[10] Simple principles of clinical trials remain powerful [J].

Califf, RM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (04) :489-491

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