Ethnic differences in allele distribution for the IL8 and IL1B genes in populations from eastern India

被引：14

作者：

Chakravorty, M

Ghosh, A

Choudhury, A

Santra, A

Hembrum, J

Roychoudhury, S

机构：

[1] Indian Inst Chem Biol, Human Genet & Genom Div, Kolkata 700032, W Bengal, India

[2] Postgrad Inst Med Educ & Res, Dept Med, Kolkata 700020, India

[3] Postgrad Inst Med Educ & Res, Dept Gastroenterol, Kolkata 700020, India

来源：

HUMAN BIOLOGY | 2004年 / 76卷 / 01期

关键词：

Indian populations; cytokine; IL8; gene; IL1B gene; single nucleotide polymorphisms (SNPS); allele frequency; haplotype structure; Brahmin population; Kayastha population; Mahishya population; Oraon population; Santhal population; castes; tribal populations of India;

D O I：

10.1353/hub.2004.0016

中图分类号：

Q98 [人类学];

学科分类号：

030303 ;

摘要：

Populations from eastern India have been examined for the allele distribution at polymorphic sites in the IL8 and IL1B genes. Significant differences in allele frequencies between caste and tribal population groups were observed. However, there are no differences in allele frequencies among various subpopulations within caste or tribal groups. We argue that different caste populations from the same geographic location can be pooled for the purpose of population association studies.

引用

收藏

页码：153 / 159

页数：7

相关论文

共 12 条

[1]

[Anonymous], 1985, MOL EVOLUTIONARY GEN

[2] The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer (vol 404, pg 398, 2000) [J].

El-Omar, EM ;

Carrington, M ;

Chow, WH ;

McColl, KEL ;

Bream, JH ;

Young, HA ;

Herrera, J ;

Lissowska, J ;

Yuan, CC ;

Rothman, N ;

Lanyon, G ;

Martin, M ;

Fraumeni, JF ;

Rabkin, CS .

NATURE, 2001, 412 (6842) :99-+

[3] Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations [J].

Goddard, KAB ;

Hopkins, PJ ;

Hall, JM ;

Witte, JS .

AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 66 (01) :216-234

[4] Genetics of infectious disease resistance [J].

Hill, AVS .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (03) :348-353

[5] Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus [J].

Hull, J ;

Ackerman, H ;

Isles, K ;

Usen, S ;

Pinder, M ;

Thomson, A ;

Kwiatkowski, D .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (02) :413-419

[6] Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma [J].

Machado, JC ;

Pharoah, P ;

Sousa, S ;

Carvalho, R ;

Oliveira, C ;

Figueiredo, C ;

Amorim, A ;

Seruca, R ;

Caldas, C ;

Carneiro, F ;

Sobrinho-Simoes, M .

GASTROENTEROLOGY, 2001, 121 (04) :823-829

[7]

MAJUMDER PP, 2000, HAPLOFREQ COMPUTER P

[8] Frequency of cytokine polymorphisms in populations from Western Europe, Africa, Asia, the Middle East and South America [J].

Meenagh, A ;

Williams, F ;

Ross, OA ;

Patterson, C ;

Gorodezky, C ;

Hammond, M ;

Leheny, WA ;

Middleton, D .

HUMAN IMMUNOLOGY, 2002, 63 (11) :1055-1061

[9] Genetics, cytokines and human infectious disease:: lessons from weakly pathogenic mycobacteria and salmonellae [J].

Ottenhoff, THM ;

Verreck, FAW ;

Lichtenauer-Kalígis, EGR ;

Hoeve, MA ;

Sanal, O ;

van Dissel, JT .

NATURE GENETICS, 2002, 32 (01) :97-105

[10] Nucleotide diversity of the TNF gene region in an African village [J].

Richardson, A ;

Sisay-Joof, F ;

Ackerman, H ;

Usen, S ;

Katundu, P ;

Taylor, T ;

Molyneux, M ;

Pinder, M ;

Kwiatkowski, D .

GENES AND IMMUNITY, 2001, 2 (06) :343-348