A DNA-based machine that can cyclically bind and release thrombin

被引：207

作者：

Dittmer, WU

Reuter, A

Simmel, FC ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Sekt Phys, Geschwister Scholl Pl 1, D-80539 Munich, Germany

[2] Ludwig Maximilians Univ Munchen, Ctr Neurosci, D-80539 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 27期

关键词：

aptamers; DNA structures; DNA; molecular devices; nanostructures;

D O I：

10.1002/anie.200353537

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A DNA aptamer structure is the basis of a molecular machine that can be instructed to grab or release the human blood-clotting Factor α-thrombin, depending on the operator DNA sequence addressing it. In the picture the aptamer structure, which assumes a conformation characterized by two stacked guanine quadruplex structures, is linked to thrombin (gray ellipse).

引用

页码：3550 / 3553

页数：4

共 25 条

[1] DNA duplex-quadruplex exchange as the basis for a nanomolecular machine [J].