Polymorphonuclear neutrophils are necessary for the recruitment of CD8+ T cells in the liver in a pregnant mouse model of Chlamydophila abortus (Chlamydia psittaci serotype 1) infection

被引:53
作者
de Oca, RM
Buendía, AJ
Del Río, L
Sánchez, J
Salinas, J
Navarro, JA
机构
[1] Univ Murcia, Fac Vet, Dept Patol Anim Microbiol & Inmunol, E-30100 Murcia, Spain
[2] Univ Murcia, Fac Vet, Dept Histol & Anat Patol, E-30100 Murcia, Spain
[3] Univ Autonoma Estado Mexico, Fac Vet, Dept Salud Anim, Toluca, Mexico
关键词
D O I
10.1128/IAI.68.3.1746-1751.2000
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The role of polymorphonuclear neutrophils (PMNs) in the development of the specific immune response against Chlamydophila abortus (Chlamydia psittaci serotype I) infection,vas studied in a pregnant mouse model involving treatment with RB6-8C5 monoclonal antibody. PMN depletion significantly affected the immune response in the liver, in which the T-lymphocyte and F4/80(+) cell populations decreased, particularly the CD8(+) T-cell population. A Th1-like response, characterized by high levels of gamma interferon without detectable levels of interleukin 4 (IL-4) in serum, was observed in both depleted and nondepleted mice, although an increased production of IL-10 was detected in the depleted group. Our results suggest that PMNs play a very important role in the recruitment of other leukocyte populations to the inflammatory foci but have little influence in the polarization of the immune specific response toward a Th1-like response.
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页码:1746 / 1751
页数:6
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