Multifactorial treatment of hypertensive men at high cardiovascular risk and low-density lipoprotein cholesterol affinity to human arterial proteoglycans

The purpose of this work was to examine in an open, randomized parallel-group study whether an intervention programme directed towards hypercholesterolaemia, smoking and diabetes mellitus in treated hypertensive men was associated with less complex formation between low-density lipoprotein (LDL) and human arterial proteoglycans than was the case with usual care. The intervention consisted mainly of non-pharmacological treatment, but drug therapy could be instituted to achieve the treatment goals in the intervention group. The intervention programme was associated with a significant reduction in body mass index, and 46% of the patients were on lipid-lowering medication at the follow-up examination. The net differences were (intervention - usual care): change in serum LDL-cholesterol, -0.48 mmol L(-1) (95% confidence interval -0.84 to -0.11 mmol L(-1)), precipitated LDL-cholesterol, -5.5 mu g (95% CI -9.0 to -1.1 mu g). The latter remained after adjustment for the difference in serum LDL-cholesterol between the groups. Our conclusion is that the multifactorial risk factor treatment programme was associated,with a reduced tendency of LDL to form complexes with human arterial proteoglycans.