Age-related changes in the murine cochlear lateral wall

被引：55

作者：

Ichimiya, I ^{[1
]}

Suzuki, M ^{[1
]}

Mogi, G ^{[1
]}

机构：

[1] Oita Med Univ, Dept Otolaryngol, Hasama, Oita 8795593, Japan

来源：

HEARING RESEARCH | 2000年 / 139卷 / 1-2期

关键词：

inner ear; sensorineural hearing loss; spiral ligament; connexin; 26; sodium-potassium-adenosinetriphosphatase; C57BL/6; mouse;

D O I：

10.1016/S0378-5955(99)00170-7

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Cochleas From C57BL/6 mice were investigated electrophysiologically and histochemically to evaluate the pathology of presbycusis. The average auditory brainstem response thresholds from 6-week-old mice were significantly lower than those of 6-month-old mice and those of I-year-old mice. Histologic observation revealed changes in the cochlea after age 6 months. Conventional hematoxylin and eosin (H&E) staining showed disorganization of the organ of Corti, a decrease in the number of spiral ganglion cells, and atrophy of the stria vascularis. Although H&E staining and type II collagen immunolabeling did not show obvious changes in the spiral ligament (SL), the density of connexin 26 staining was reduced in this region. Sodium-potassium-adenosinetriphosphatase immunolabeling was increased in the St., whereas its average density was not significantly altered in the stria vascularis. These results suggest that the SL could be among the regions responsible for cochlear malfunction with aging. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：116 / 122

页数：7

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