Progress of the smart bomb cancer virus.

被引:17
作者
Lowe, SW
机构
[1] Cold Spring Harbor,Cold Spring Harbor Laboratory
关键词
D O I
10.1038/nm0697-606
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A mutant adenovirus capable of preferentially destroying cancer cells shows promise in preclinical studies (639–645).
引用
收藏
页码:606 / 608
页数:3
相关论文
共 10 条
[1]   An adenovirus mutant that replicates selectively in p53-deficient human tumor cells [J].
Bischoff, JR ;
Kim, DH ;
Williams, A ;
Heise, C ;
Horn, S ;
Muna, M ;
Ng, L ;
Nye, JA ;
SampsonJohannes, A ;
Fattaey, A ;
McCormick, F .
SCIENCE, 1996, 274 (5286) :373-376
[2]   WILD-TYPE P53 MEDIATES APOPTOSIS BY E1A, WHICH IS INHIBITED BY E1B [J].
DEBBAS, M ;
WHITE, E .
GENES & DEVELOPMENT, 1993, 7 (04) :546-554
[3]   Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor [J].
Dobner, T ;
Horikoshi, N ;
Rubenwolf, S ;
Shenk, T .
SCIENCE, 1996, 272 (5267) :1470-1473
[4]   ENHANCED EXPRESSION OF P53 IN HUMAN-CELLS INFECTED WITH MUTANT ADENOVIRUSES [J].
GRAND, RJA ;
GRANT, ML ;
GALLIMORE, PH .
VIROLOGY, 1994, 203 (02) :229-240
[5]   ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents [J].
Heise, C ;
SampsonJohannes, A ;
Williams, A ;
McCormick, F ;
VonHoff, DD ;
Kirn, DH .
NATURE MEDICINE, 1997, 3 (06) :639-645
[6]   STABILIZATION OF THE P53 TUMOR SUPPRESSOR IS INDUCED BY ADENOVIRUS-5 E1A AND ACCOMPANIES APOPTOSIS [J].
LOWE, SW ;
RULEY, HE .
GENES & DEVELOPMENT, 1993, 7 (04) :535-545
[7]  
LOWE SW, 1993, CELL, V74, P954
[8]   Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region [J].
Somasundaram, K ;
ElDeiry, WS .
ONCOGENE, 1997, 14 (09) :1047-1057
[9]   The cat and mouse games that genes, viruses, and cells play [J].
Weinberg, RA .
CELL, 1997, 88 (05) :573-575
[10]   INHIBITION OF P53 TRANSACTIVATION REQUIRED FOR TRANSFORMATION BY ADENOVIRUS EARLY 1B-PROTEIN [J].
YEW, PR ;
BERK, AJ .
NATURE, 1992, 357 (6373) :82-85