Efficient enantioselective additions of terminal alkynes and aldehydes under operationally convenient conditions

被引：234

作者：

Boyall, D ^{[1
]}

Frantz, DE ^{[1
]}

Carreira, EM ^{[1
]}

机构：

[1] ETH Honggerberg, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 15期

关键词：

D O I：

10.1021/ol026282k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The enantioselective addition reaction of terminal acetylenes and aldehydes mediated by Zn(OTf)(2) and N-methyl ephedrine can be conducted with reagent grade solvent containing 84-1000 ppm H2O. The products can be isolated in high yield and useful enantioselectivities (up to 99% ee).

引用

页码：2605 / 2606

页数：2

共 10 条

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