Prefrontal cortex fMRI signal changes are correlated with working memory load

被引：220

作者：

Manoach, DS

Schlaug, G

Siewert, B

Darby, DG

Bly, BM

Benfield, A

Edelman, RR

Warach, S

机构：

[1] HARVARD UNIV, SCH MED, BETH ISRAEL HOSP, DEPT NEUROL, BOSTON, MA 02215 USA

[2] HARVARD UNIV, SCH MED, BETH ISRAEL HOSP, DEPT RADIOL, BOSTON, MA 02215 USA

[3] ROYAL MELBOURNE HOSP, DEPT NEUROL, PARKVILLE, VIC 3052, AUSTRALIA

来源：

NEUROREPORT | 1997年 / 8卷 / 02期

关键词：

functional MRI; intraparietal sulcus; prefrontal cortex; working memory;

D O I：

10.1097/00001756-199701200-00033

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE investigated whether a nonspatial working memory (WM) task would activate dorsolateral prefrontal cortex (DLPFC) and whether activation would be correlated with WM load. Using functional magnetic resonance imaging we measured regional brain signal changes in 12 normal subjects performing a continuous performance, choice reaction time task that requires WM. A high WM load condition was compared with a non-WM choice reaction time control condition (WM effect) and a low WM load condition (load effect). Significant changes in signal intensity occurred in the DLPFC, frontal motor regions and the intraparietal sulcus (IPS) in both comparisons. These findings support the role of DLPFC and IPS in WM and suggest that signal changes in DLPFC correlate with WM load.

引用

页码：545 / 549

页数：5

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