Methylation pattern of CDH13 gene in digestive tract cancers

被引：43

作者：

Hibi, K ^{[1
]}

Kodera, Y ^{[1
]}

Ito, K ^{[1
]}

Akiyama, S ^{[1
]}

Nakao, A ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668560, Japan

来源：

BRITISH JOURNAL OF CANCER | 2004年 / 91卷 / 06期

关键词：

CDH13; oesophageal cancer; gastric cancer;

D O I：

10.1038/sj.bjc.6602095

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, the loss of CDH13 (T-cadherin, H-cadherin) gene expression accompanied by CDH13 promoter methylation was identified in colon cancers. We examined CDH13 methylation in oesophageal and gastric carcinomas. Five of 37 oesophageal cancers (14%) and 23 of 66 gastric cancers (35%) demonstrated abnormal methylation of the CDH13 promoter. Abnormal methylation was frequently found in gastric cancers of patients at all clinical stages just as in E-cadherin, another of the cadherin family, suggesting that these cancers could be methylated at an early stage. These results suggested that CDH13 might play a variety of roles depending on the tissue type.

引用

页码：1139 / 1142

页数：4

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