Opinion - Building epithelial architecture: insights from three-dimensional culture models

被引：483

作者：

O'Brien, LE

Zegers, MMP

Mostov, KE ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm859

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

How do individual cells organize into multicellular tissues? Here, we propose that the morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic differentiation programme that drives formation of a lumen-enclosing monolayer, and a growth factor-induced, transient de-differentiation that allows this monolayer to be remodelled.

引用

页码：531 / 537

页数：7

共 63 条

[1] Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase [J].

Birchmeier, C ;

Gherardi, E .

TRENDS IN CELL BIOLOGY, 1998, 8 (10) :404-410

[2]

Blatchford DR, 1999, J CELL PHYSIOL, V181, P304, DOI 10.1002/(SICI)1097-4652(199911)181:2<304::AID-JCP12>3.0.CO

[3]

2-5

[4] POLARITY REVERSAL OF INSIDE-OUT THYROID-FOLLICLES CULTURED WITHIN COLLAGEN GEL - REEXPRESSION OF SPECIFIC FUNCTIONS [J].

CHAMBARD, M ;

VERRIER, B ;

GABRION, J ;

MAUCHAMP, J .

BIOLOGY OF THE CELL, 1984, 51 (03) :315-326

[5] EPITHELIAL DIFFERENTIATION IN THE FETAL-RAT COLON .1. PLASMA-MEMBRANE PHOSPHATASE-ACTIVITIES [J].

COLONY, PC ;

NEUTRA, MR .

DEVELOPMENTAL BIOLOGY, 1983, 97 (02) :349-363

[6] SIGNALS FOR DEATH AND SURVIVAL - A 2-STEP MECHANISM FOR CAVITATION IN THE VERTEBRATE EMBRYO [J].

COUCOUVANIS, E ;

MARTIN, GR .

CELL, 1995, 83 (02) :279-287

[7]

DAVIS GE, IN PRESS MICROCIRCUL

[8] Origins of cell polarity [J].

Drubin, DG ;

Nelson, WJ .

CELL, 1996, 84 (03) :335-344

[9] A ROLE FOR THE DYSTROPHIN-GLYCOPROTEIN COMPLEX AS A TRANSMEMBRANE LINKER BETWEEN LAMININ AND ACTIN [J].

ERVASTI, JM ;

CAMPBELL, KP .

JOURNAL OF CELL BIOLOGY, 1993, 122 (04) :809-823

[10] ANGIOGENESIS INVITRO [J].

FOLKMAN, J ;

HAUDENSCHILD, C .

NATURE, 1980, 288 (5791) :551-556

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