Cyclic PNA hexamer-based compound: modelling, synthesis and inhibition of the HIV-1 RNA dimerization process

被引：41

作者：

Schwergold, C

Depecker, G

Di Giorgio, C

Patino, N

Jossinet, F

Ehresmann, B

Terreux, R

Cabrol-Bass, D

Condom, R ^{[1
]}

机构：

[1] Univ Nice, Chim Bioorgan Lab, CNRS, UMR 6001,UNSA, F-06108 Nice 2, France

[2] CNRS, Inst Biol Mol & Cellulaire, UPR 9002, F-64084 Strasbourg, France

[3] Univ Nice, Lab ASI Equipe Chimiometrie & Modelisat, F-06108 Nice 2, France

来源：

TETRAHEDRON | 2002年 / 58卷 / 28期

关键词：

PNA hexamer; HIV-1 dimerization process; synthesis;

D O I：

10.1016/S0040-4020(02)00527-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cyclic molecule constituted by (i) a hexameric PNA moiety complementary to six among the nine residues of the dimerization initiation site loop of HIV-1 and (ii) a spacer tethering the N- to the C-extremities of the PNA, has been elaborated to inhibit the dimerization process of HIV-1 genome. This compound has been synthesized following a liquid-phase procedure (fully protected backbone approach). Preliminary agarose gel electrophoresis analyses have shown that the cyclic PNA conjugate is able to inhibit the HIV-1 dimerization. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：5675 / 5687

页数：13

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