Fragile X premutation alleles in SCA, ET, and parkinsonism in an Asian cohort

被引：54

作者：

Tan, EK

Zhao, Y

Puong, KY

Law, HY

Chan, LL

Yew, K

Tan, C

Shen, H

Chandran, VR

Teoh, ML

Yih, Y

Pavanni, R

Wong, MC

Ng, IS

机构：

[1] Singapore Gen Hosp, Natl Inst Neurosci, Dept Neurol, Singapore 169608, Singapore

[2] Singapore Gen Hosp, Natl Inst Neurosci, Dept Clin Res, Singapore 169608, Singapore

[3] Singapore Gen Hosp, Natl Inst Neurosci, Dept Diagnost Radiol, Singapore 169608, Singapore

[4] Singapore Gen Hosp, Natl Inst Neurosci, Dept Hlth Screening, Singapore 169608, Singapore

[5] SingHlth Res, Singapore, Singapore

[6] KK Women & Children Hosp, Singapore, Singapore

来源：

NEUROLOGY | 2004年 / 63卷 / 02期

关键词：

D O I：

10.1212/01.WNL.0000130199.57181.7B

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Among 367 subjects, the authors analyzed 167 patients with essential tremor, sporadic progressive cerebellar ataxia, multiple-system atrophy, and atypical parkinsonism and 200 healthy control subjects for FMR1 premutation alleles. None of the subjects carried alleles within the premutation range. These findings suggest that in the absence of other supportive clinical or imaging features, the cost-effectiveness of routine fragile X tremor/ataxia syndrome screening in this Asian cohort with movement disorders was low.

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页码：362 / 363

页数：2

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