Live-attenuated virus vaccines for respiratory syncytial and parainfluenza viruses: applications of reverse genetics

被引:62
作者
Murphy, BR [1 ]
Collins, PL [1 ]
机构
[1] NIAID, Resp Viruses Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1172/JCI200216077
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:21 / 27
页数:7
相关论文
共 35 条
[1]   A recombinant human parainfluenza virus type 3 (PIV3) in which the nucleocapsid N protein has been replaced by that of bovine PIV3 is at attenuated in primates [J].
Bailly, JE ;
McAuliffe, JM ;
Durbin, AP ;
Elkins, WR ;
Collins, PL ;
Murphy, BR .
JOURNAL OF VIROLOGY, 2000, 74 (07) :3188-3195
[2]  
CHANOCK RM, 2001, FIELDS VIROLOGY, V1, P1341
[3]   Rational design of live-attenuated recombinant vaccine virus for human respiratory syncytial virus by reverse genetics [J].
Collins, PL ;
Whitehead, SS ;
Bukreyev, A ;
Fearns, R ;
Teng, MN ;
Juhasz, K ;
Chanock, RM ;
Murphy, BR .
ADVANCES IN VIRUS RESEARCH, VOL 54, 1999, 54 :423-451
[4]   PRODUCTION OF INFECTIOUS HUMAN RESPIRATORY SYNCYTIAL VIRUS FROM CLONED CDNA CONFIRMS AN ESSENTIAL ROLE FOR THE TRANSCRIPTION ELONGATION-FACTOR FROM THE 5'-PROXIMAL OPEN READING FRAME OF THE M2 MESSENGER-RNA IN GENE-EXPRESSION AND PROVIDES A CAPABILITY FOR VACCINE DEVELOPMENT [J].
COLLINS, PL ;
HILL, MG ;
CAMARGO, E ;
GROSFELD, H ;
CHANOCK, RM ;
MURPHY, BR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) :11563-11567
[5]  
Collins PL., 2001, FIELDS VIROLOGY, P1443
[6]   Mutations in the C, D, and V open reading frames of human parainfluenza virus type 3 attenuate replication in rodents and primates [J].
Durbin, AP ;
McAuliffe, JM ;
Collins, PL ;
Murphy, BR .
VIROLOGY, 1999, 261 (02) :319-330
[7]   Recovery of infectious human parainfluenza virus type 3 from cDNA [J].
Durbin, AP ;
Hall, SL ;
Siew, JW ;
Whitehead, SS ;
Collins, PL ;
Murphy, BR .
VIROLOGY, 1997, 235 (02) :323-332
[8]   Expression of the surface glycoproteins of human parainfluenza virus type 3 by bovine parainfluenza virus type 3, a novel attenuated virus vaccine vector [J].
Haller, AA ;
Miller, T ;
Mitiku, M ;
Coelingh, K .
JOURNAL OF VIROLOGY, 2000, 74 (24) :11626-11635
[9]   Isolation of an avirulent mutant of Sendai virus with two amino acid mutations from a highly virulent field strain through adaptation to LLC-MK2 cells [J].
Itoh, M ;
Isegawa, Y ;
Hotta, H ;
Homma, M .
JOURNAL OF GENERAL VIROLOGY, 1997, 78 :3207-3215
[10]   Recombinant respiratory syncytial viruses with deletions in the NS1, NS2, SH, and M2-2 genes are attenuated in vitro and in vivo [J].
Jin, H ;
Zhou, H ;
Cheng, X ;
Tang, R ;
Munoz, M ;
Nguyen, N .
VIROLOGY, 2000, 273 (01) :210-218