Focal adhesions - the cytoskeletal connection

被引：480

作者：

Critchley, DR ^{[1
]}

机构：

[1] Univ Leicester, Dept Biochem, Leicester LE1 7RH, Leics, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0955-0674(99)00067-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Cellular contacts with the extracellular matrix are regulated by the Rho family of GTPases through their effects on both the actin and the microtubule cytoarchitecture. Recent genetic, biochemical and structural data have highlighted the role played by a subset of actin-binding proteins in coupling integrins to cytoskeletal actin and in assembling signalling complexes that are important for cell motility and cell proliferation.

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页码：133 / 139

页数：7

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