Beneficial effect of L-arginine for stroke-like episode in MELAS

被引：48

作者：

Kubota, M

Sakakihara, Y

Mori, M

Yamagata, T

Momoi-Yoshida, M

机构：

[1] Univ Tokyo, Dept Pediat, Bunkyo Ku, Tokyo 1138655, Japan

[2] Jichi Med Sch, Dept Pediat, Minami Kawachi, Tochigi 3290498, Japan

来源：

BRAIN & DEVELOPMENT | 2004年 / 26卷 / 07期

关键词：

mitochondrial myopathy; encephalopathy; lactic acidosis; and stroke-like episodes; L-arginine; magnetic resonance spectroscopy; stroke-like episodes;

D O I：

10.1016/j.braindev.2004.01.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We here reported the clinical course and therapeutic details of a 16-year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had had five stroke-like episodes (two episodes were clinically mild, while the three subsequent episodes were severe). Among the three episodes, the symptoms improved earliest and magnetic resonance spectroscopy abnormality was minimal when given L-arginine in addition to prednisolone, glycerol and edalavone. L-arginine administration during the acute phase of MELAS might be a potential therapy to reduce brain damage due to mitochondrial dysfunction. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：481 / 483

页数：3

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