A ruthenium-grafted hydrotalcite as a multifunctional catalyst for direct α-alkylation of nitriles with primary alcohols

被引：235

作者：

Motokura, K ^{[1
]}

Nishimura, D ^{[1
]}

Mori, K ^{[1
]}

Mizugaki, T ^{[1
]}

Ebitani, K ^{[1
]}

Kaneda, K ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn Sci, Dept Mat Engn Sci, Toyonaka, Osaka 5608531, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 18期

关键词：

D O I：

10.1021/ja049181l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Treatment of a hydrotacite, Mg6Al2(OH)16CO3, with an aqueous solution of RuCl3·nH2O afforded a monomeric Ru(IV) species on the surface of the hydrotalcite. This novel Ru-grafted hydrotalcite (Ru/HT) efficiently catalyzed α-alkylation of nitriles with primary alcohols through the cooperative catalysis between the Ru species and the surface base sites. The catalyst system could be further extended for the one-pot synthesis of α,α-dialkylated phenylacetonitriles via the base-catalyzed Michael reaction of α-alkylated phenylacetonitrile with activate olefins. Copyright © 2003 American Chemical Society.

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页码：5662 / 5663

页数：2

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